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Research Newsletter
CWRU ORA - News and Funding Opportunities
August 4, 2017  

Funding Opportunities

American Skin Association - Calder Research Scholar Award in Vitiligo/Pigment Cell Disorders
American Skin Association (ASA) invites the submission of applications for its Calder Research Scholar Award in Vitiligo/Pigment Cell Disorders in the amount of $60,000 to foster the career development of a young investigator working at the level of instructor through associate professor in the field of dermatology or cutaneous biology. The aim of the program is to provide bridge support for young investigators. Special consideration will be given to individuals without significant prior support. A second year of funding may be requested upon receipt and review of a final progress report and reapplication.

If an awardee receives a career development award or other comparable research award from the NIH, the Dermatology Foundation, or similar organization, the awardee must choose between it and this research award. If the awardee chooses the other award, then he/she may not receive any remaining installments of funding from ASA.

The individual must have a strong career goal within the field of dermatology and be dedicated to the furtherance of knowledge concerning vitiligo/pigment cell disorders. The research must be focused on new discoveries in the basic or translational medical sciences that impact the understanding or treatment of vitiligo/pigment cell disorders.

Preference will be given to those under the age of 45 as of June 30, 2018 with a rank of instructor up through associate professor (or the institutional equivalent). First preference will be given to those working in a department or division of dermatology, and second preference to those with a close working relationship to dermatology.

If an MD, the candidate must be Board certified in dermatology with at least three years of in-depth experience in investigative dermatology. If a PhD, the candidate must have at least three years of postdoctoral or faculty-level experience in investigative dermatology.

The candidate must be identified as a current or future leader in dermatological investigation, and must spend at least 80% of his/her professional time in research.

Application Deadline: October 1, 2017

For more information visit the ASA website.

Gates Foundation
The Bill & Melinda Gates Foundation has issued a Request of Proposals for its Novel Artemisinin Manufacturing Technologies program.

The goal of the project is to develop novel approaches through the proof of concept stage for the manufacturing of artemisinin and/or its precursors as a starting material or intermediate to prepare artemisinin-based active pharmaceutical ingredients. These approaches should demonstrate the potential — with a high probability of success — to meet aggressive cost targets when being practiced at commercial scale.

The focus of the RFP is on the early research and lab-scale proof of concept testing of novel technologies to supply artemisinin for artemisinin-based combination therapies (ACTs) to treat malaria. Awards will be made in three target areas including artemisinin precursor (i.e. AA) production, chemical conversion of AA to artemisinin, and the direct production of artemisinin. The total value of all awards combined is estimated at $4.5 million, with individual awards not to exceed $1 million each, for programs of up to twelve months.

This project intends to address the problems described above through the identification, optimization, and lab-scale proof of concept demonstration of new technologies for the consistent, large scale, low cost, manufacture of high quality semisynthetic artemisinin and/or its precursors and analogs at existing manufacturing infrastructure.

As the foundation recognizes that many interested parties may not have all the requisite capabilities in-house, proposers are highly encouraged to collaborate with partners, if needed,

It is anticipated (but not guaranteed) that successful awardees will be requested to submit a further proposal for additional development work, scale-up to pilot scale and generation of the necessary materials (e.g. cell banks) and technology transfer packages to enable manufacturing at multiple existing manufacturing facilities.

To be eligible, applicants must be open to collaboration; be committed to providing global access to the technologies developed for the ultimate manufacturing of artemisinin; and have overall financial health.

There are two deadlines to accommodate 1) potential rapid responses and awards for responders that can meet the tighter timelines and 2) to allow for more time where it is required for partnering and/or the crafting of responses. Those deadlines are August 5, 2017, and September 29, 2017, respectively.

For more information visit the Gates Foundation website.

HHS: Central Neural Mechanisms of Age-Related Hearing Loss (R01)
The purpose of this Funding Opportunity Announcement (FOA) is to encourage basic or clinical research applications that investigate central neural mechanisms of age-related hearing loss in older adults and/or in relevant animal models. This FOA is driven by the need to address a major gap in our understanding of the central pathways and neural networks that are involved in hearing loss and how these may be altered in the context of the aging brain, as well as how natural aging influences central auditory plasticity.

Application Deadline: November 8, 2017

For more information visit the Grants.Gov website.

Hilda and Preston Davis Foundation
Established in 2009, the Hilda and Preston Davis Foundation was created to “ advance the development of all areas of the lives of children and young adults…with special emphasis…on those suffering from eating disorders.” The primary goal of The Hilda and Preston Davis Foundation Awards Program for Eating Disorders Research is to support innovative, clinically relevant research that seeks to understand the underlying biology of eating disorders, including anorexia nervosa and bulimia nervosa, leading to improved patient care. To meet this goal, the Program provides vital support to Senior Postdoctoral Fellows and Junior Faculty Investigators working in non-profit academic, medical and research institutions in the United States to build a strong workforce dedicated to the etiology of eating disorders, its associated pathologies, and to drive therapeutic and treatment development. Applicants at the Junior Faculty level should refer to the Guidelines for Junior Faculty Investigators.

The new Davis Foundation Awards Program for Eating Disorders Research is designed to distribute up to two (2) Senior Postdoctoral Fellowships annually beginning with the 2018 grant cycle. The funding level for the two-year senior postdoctoral fellowship award is estimated at $110,000 each, but will be adjusted based upon awardee experience and will match current NIH fellowship levels. Funding will begin April 1, 2018 – March 31, 2020.

In keeping with the Foundation’s mission, the Program supports all areas of basic and translational research in eating disorders. Obesity research is outside the scope of this program. Proposals are encouraged that address current roadblocks to progress in the eating disorder field and include, but are not limited to, the interrogation of the genetics and associated molecular pathways that are specifically relevant to eating disorder pathology, the development of clinically-relevant mammalian animal models and systems biology approaches that address disease complexity and heterogeneity. Animal model research should be limited to mammals and exploratory clinical trials may be considered.

To advance our understanding of the underlying biology of eating disorders while maintaining relevance to human pathobiology and treatment, proposals will be required to provide support documentation taking the clinical perspective of the proposal into consideration. For example, such documentation will support the relevance of preclinical animal models to the human disease and assessing the appropriateness of proposed neural circuitry or cell-based studies for addressing disease-related questions. These recommended changes in the Program are designed keep the relevance of proposed projects sharply focused on eating disorders.

Application Deadline: September 29, 2017

For more informaiton, visit the HRIA website.

National Endowment for the Arts - NEA Literature Fellowships: Translation Projects, FY2019
Through fellowships to published translators, the National Endowment for the Arts supports projects for the translation of specific works of prose, poetry, or drama from other languages into English.

Grants are for $12,500 or $25,000.

Application Deadline: December 5, 2017
For more information visit the NEA website.

Limited Submission Reminder: The Greenwall Foundation: Greenwall Faculty Scholars Program

Key Deadlines: August 15, 2017 (CWRU internal letter of intent), October 25, 2017 (CWRU internal submission deadline); November 1, 2017 (Sponsor submission deadline).

The Greenwall Faculty Scholars Program in Bioethics is a career development award to enable junior faculty members to carry out innovative bioethics research. Each year about three Greenwall Faculty Scholars are selected to receive 50 percent salary support for three years to enable them to develop their research program.

The Greenwall Faculty Scholars Program in Bioethics supports research that goes beyond current work in bioethics to help resolve pressing ethical issues in clinical care, biomedical research, and public policy.

Scholars and Alumni/ae attend twice-yearly meetings, where they present their work in progress, receive feedback and mentoring from the Faculty Scholars Program Committee and other Scholars, and have the opportunity to develop collaborations with other researchers. The ongoing involvement of Alumni/ae with the Program provides them ongoing opportunities for professional development and feedback and engages them in mentoring of younger Scholars.

The Greenwall Faculty Scholars Program creates a community that enhances future bioethics research by Scholars and Alumni/ae.

The Faculty Scholars Program Committee provides oversight and direction for the program and is involved not only with selection of the Scholars but with mentoring and faculty development activities.

What does the Faculty Scholars Program Committee look for in letters of intent?

1. The proposed project. Does it address an important bioethics issue in an innovative way? Does the application show how the project will make a significant advance beyond what has already been published on the topic? Is the applicant thinking about the conceptual and normative ethical issues regarding the topic in a rigorous and creative way? We commonly receive proposals to carry out an empirical study of a topic that has a bioethics component. The most successful of these proposals have already conducted enough empirical research to allow the applicant to discuss what conceptual or normative bioethics issues they will focus on. Because the Greenwall Faculty Scholar award supports only effort of the Scholar, other support will be needed to collect and analyze new empirical data. Applicants who propose to carry out focus groups and a survey on a topic that intersects with bioethics, without a strong conceptual framework, normative analysis, and plans for mentoring on these research methodologies are unlikely to be successful. Applicants who are extending previous empirical research to a new population or clinical condition are unlikely to be successful unless there is a persuasive demonstration of how their proposed extension is innovative.

2. Demonstrated ability to carry out innovative bioethics research. At the full application stage of the selection process, the Faculty Scholars Program Committee carefully reads a peer-reviewed first authored bioethics paper written by the applicant that has been published or is in press. Because this demonstrated publication of bioethics research is given great weight, applicants who have not yet published a strong bioethics article will not be successful. Scholars who have published a book should submit a chapter that best indicates the quality of their thinking in bioethics.

Number of Applications Allowed: Two

Amount of Funding: 50 percent salary plus benefits for three years, up to the NIH salary cap, with 10% institutional costs for the salary and benefits. In addition, $5,000 will be provided each year for limited project support and travel (no indirect costs provided for these items).

For more information on this limited submission opportunity, visit the Office of Research Administration website.

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